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J Radiat Prot > Volume 15(2); 1990 > Article
Journal of Radiation Protection 1990;15(2):1-0.
Inhibition of $N^{+}-K^{+}$ Adenosine Triphosphatase Activity in Fisher Rats by Uranyl Nitrate
Lee, Kee-Ho;Lee, Je-Ho;Lee, Soo-Yong;Park, Sang-Yoon;Lee, Seung-Hoon;Yun, Taik-Koo;Ryu, Young-Wun;Lim, In-Kyoung;
ABSTRACT
An attempt was made to test the possibility of a major role for the $Na^{+}-K^{+}$ adenosine triphosphatase (ATPase)system in the diuresis induced by uranyl nitrate(UN). Fisher 344 rats were intravenously injected with UN(5 mg/kg, 15 mg/kg and 30 mg/kg). Urinary excretion of $Na^{+};and;K^{+}$ significantly increased in 24 h exposure on the UN and then decreased below the normal level 3 days after the treatment. $Na^{+}-K^{+}$ ATPase activity of kidney was significantly inhibited in high dosages of UN 15mg/kg and UN 30 mg/kg 3-5 days after injection. And then the recovery of the enzyme activity was observed within 5-10 days after injection, at which the regeneration of the tubular cells occurred.
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