KCCH cyclotron neutron 및 $^{60}Co;{gamma}-ray$에 의한 인체 말초혈액 임파구의 염색체 이상측정
김성호;김태환;정인용;조철구;고경환;류성렬;
Radiation-Induced Chromosome Aberration in Human Peripheral Blood Lymphocytes In Vitro : RBE Study with Neutrons and $^{60}Co;{gamma}-rays$.
Kim, Sung-Ho;Kim, Tae-Hwan;Chung, In-Yong;Cho, Chul-Koo;Koh, Kyoung-Hwan;Yoo, Seong-Yul;
ABSTRACT
The frequencies of KCCH cyclotron neutron (30 cGy/min) or $^{60}Co;{gamma}-rays$ (210 cGy/min)-induced asymmetrical interchanges (dicentrics and centric rings) and acentric fragments (deletion) at several doses were measured in the normal human peripheral blood lymphocytes Chromosome aberrations were scored at the first nitosis after stimulation with phytohemagglutinin. The neutron and y-ray data were analysed on linear, power-law, quadratic and linear-quadratic model . When the dicentrics and centric rings of ${gamma}-rays$ datas were pooled and fitted to these model, good fits were obtained to power-law $[Y=(5.81{pm}1.96){times}10^6D^{1.93+0.06},; P=0.931]$, quadratic $[Y=(3.91{pm}0.09){times}10^{-6}D^2,;P=0.972]$ an linear-Quadrati model $[Y=(6.55{pm}6.83){times}10^{-5}D+(3.72{pm}0.22){times}10^{-6}D^2; P=0.922]$, except for linear model (P=0.067) As in the case of neutron data, the best fit was obtained to the linear model $(Y=(6.12{pm}0.17){times}10^{-3};D-0.22,;P=0.987]$ and good fits were obtained to power-law$[Y=(5.36{pm}3.02) {times}10^{-4}D^{1.42+0.11},; P=0.601]$ and linear-quadratic model$[Y=(2.43{pm}0.70){times}10^{-3}D+(1.21{pm}0.39){times}10^{-7}D^2$, ;P=0.415], except for quadratic model (P<0.005). The relative biological effectiveness (RBE) of neutron compared with y-ray was estimated by best fitting model. In the asymmetrical interchanges range between 0.1 and 1.5 per cell, the RBE was found to be $2.714{pm}0.408$.
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