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J Radiat Prot > Volume 20(2);1995 > Article
Journal of Radiation Protection 1995;20(2):97.
인체 말초 혈액 림프구에서 저선량 방사선 조사에 의해 유도되는 적응 반응
김정희;이경종;조철구;류성렬;김태환;김성호;
Adaptive Response Induced by Low Dose Ionizing Radiation in Human Lymphocytes
Kim, Jeong-Hee;Lee, Kyung-Jong;Cho, Chul-Koo;Yoo, Seong-Yul;Kim, Tae-Hwan;Kim, Sung-Ho;
ABSTRACT
Adaptive response induced by low dose ${gamma}-ray$ irradiation in human peripheral lymphocytes was examimed. Human lymphocytes were exposured to low dose of ${gamma}-ray$ (priming dose, 0.01Gy) followed by high dose (challenging dose, 1.5Gy) after various time intervals (4, 7, 20 hours). Frequencies of micronuclei were enumerated in both primed and unprimed groups. Maximum reduction in frequency of micronuclei was observed when challenging dose irradiation was followed by priming dose after 4hr incubation period. When challenging doses were irradiated 7 or 20hr after priming dose, frequencies of micronuclei were reduced slighty. However, these reduction were not statistically significant. In this study, human peripheral lymphocytes were irradiated at Go phase and they showed adaptive response induced by low dose radiation. Since micronucleus assay is relatively simpler and faster than other methods, it may be a good tool for evaluating radiation-induced adaptive responses.
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Mechanism of Radioresistance Induced by Low-Dose Irradiation  1996 ;21(2)
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