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J Radiat Prot > Volume 37(3);2012 > Article
Journal of Radiation Protection 2012;37(3):159. doi: https://doi.org/10.14407/jrp.2012.37.3.159
저선량율 방사선 조사한 BALB/c 마우스에서의 영향평가
김성대;공은지;배민지;양광모;김중선;
Bioassay in BALB/c mice exposed to low dose rate radiation
Kim, Sung-Dae;Gong, Eun-Ji;Bae, Min-Ji;Yang, Kwang-Mo;Kim, Joong-Sun;
ABSTRACT
The present study was performed to investigate the toxicity of low-dose-rate irradiation in BALB/c mice. Twenty mice of each sex were randomly assigned to four groups of five mice each and were exposed to 0 (sham), 0.02, 0.2, or 2 Gy, equivalents to low-dose-rate irradiation to 3.49 $mGy{cdot}h^{-1}$. Urine, blood, and blood biochemistry were analyzed, and organ weight was measured. The low-dose-rate irradiation did not induce any toxicologically significant changes in mortality, clinical signs, body weight, food and water consumption, urinalysis, and serum biochemistry. However, the weights of reproductive organs including the testis, ovary, and uterus decreased in a dose-dependent manner. Irradiation at 2 Gy significantly decreased the testis, ovary, and uterus weights, but did not change the weights of other organs. There were no adverse effects on hematology in any irradiated group and only the number of neutrophils increased dose dependently. The low-dose-rate irradiation exposure did not cause adverse effects in mice at dose levels of 2 Gy or less, but the reproductive systems of male and female mice showed toxic effects.
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