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J Radiat Prot > Volume 19(3); 1994 > Article
Journal of Radiation Protection 1994;19(3):230-0.
카이토산을 이용한 방사성스트론튬 오염의 치료
The Removal of Contaminated Radiostrontium from Mice by Water Soluble Chitosan
Bom, Hee-Seung;Kim, Kwang-Yoon;Yang, Kwang-Hee;Chae, Ki-Moon;Choi, Keun-Hee;Song, Ho-Chun;Kim, Ji-Yeul;
The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium (Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were $57.7{pm}1.9%,;54.4{pm}1.2%$, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were' ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums(P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. Further studies were needed to elucidate the mechanism of the removal.
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