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J Radiat Prot > Volume 19(3); 1994 > Article
Journal of Radiation Protection 1994;19(3):179-0.
생쥐의 난소내 스테로이드호르몬 농도에 미치는 ${gamma}$-선의 영향
${gamma}-ray$ Effects on Steroid Hormone Concentration of Mouse Ovarian Follicles
Lee, Young-Keun;Kim, Jin-Kyu;Yoon, Yong-Dal;
Mice were whole body irradiated with dose of 2.88Gy and 7.2Gy(Co-60) in order to observe the morphological and functional changes in radio sensitive mouse ovary. Microtechnical sectionates of $7{mu}m$ thickness from ovary were made for light microscopy and concentrations of progesterone, testosterone and estradiol in ovarian homogenates were analyzed by radioimmunoassay. Gamma radiation resulted in the increase of atretic ratio of preantral and antral follicles, the increase of progesterone concentration in ovarian homogenates, and the low level of testosterone and estradiol. It is suggested that radiation protect the activity of $3{beta}-HSD$(hydroxysteroid dehydrogenase) and isomerase in the follicular theca cell followed by low level of testosterone and estradiol and thereafter follicular atresia proceed.
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