| 방사선 장해에 대한 백작약의 방호효과 |
| 오헌;박혜란;정일윤;김성호;조성기; |
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| Protective Effects of Paeonia japonica against Radiation-induced Damage |
| Oh, Heon;Park, Hae-Ran;Jeong, Ill-Yun;Kim, Sung-Ho;Jo, Sung-Kee; |
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| ABSTRACT |
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We investigated the effect of Paeonia japonica (PJ) on radiation-induced oxidative damage to macromolecules in vitro and in vivo. The PJ reduced the tail moment (TM) which was a marker of DNA strand break in single-cell gel electrophoresis (SCGE; comet assay) in the human peripheral blood lymphocytes. Lipid peroxidation in the liver of the ICR mouse, measured as malondialdehyde (MDA), was also reduced by PJ administration. Ethanol fraction of PJ was more effective than polysaccharide fraction of that on reduction of TM in SCGE and lipid peroxidation. Also, Their activities to scavenge DPPH radicals and hydroxyl radicals were observed in vitro, and the activities were due to its ethanol fraction. It is plausible that scavenging of flee radicals by PJ extract may have played an important role in providing the protection against the radiation-induced damage. These results indicated that Paeonia japonica might be a useful radioprotector, especially since it is a relatively nontoxic natural product. |
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