자외선 유도 피부주름 및 암발생에 대한 누에동충하초($Paecilomyces$$japonica$)의 보호효과 평가
이해준;문창종;김종춘;정우희;조성기;장종식;김성호;
Evaluation of the Photoprotective Effect of Dongchongxiacao ($Paecilomyces$$japonica$) Extract against Ultraviolet Radiation-induced Skin Wrinkling and Cancer
To evaluate the ability of Dongchongxiacao ($Paecilomyces$$japonica$) extract (PJE) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairless mice and PJE-treated mice exposed chronically to ultraviolet (UV) were examined. The skin of the UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles across the back. PJE-treated mice showed a significantly decreased wrinkling score. By the 22nd week, 88.9% (i.p. with saline) or 44.4% (topical administration with cream base) of the UV-irradiated mice developed at least one tumor. PJE delayed tumor onset significantly. PJE (i.p.) was also effective in reducing the occurrence of UV radiation-induced skin tumors and reduced the number of tumors per mouse. After 22 weeks of treatment, 80.0% (i.p.) and 75.0% (topical) of the mice treated with PJE were tumor-free. Tumor multiplicity was reduced by 96.2% (i.p.) in the PJE treated groups. It is noted that skin that is chronically exposed to UV is subject to photoaging and photocarcinogenesis and regular use of PJE would prevent these photodamaging effects of UV.
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