| Home | E-Submission | Sitemap | Contact Us |  
top_img
J Radiat Prot > Volume 10(2); 1985 > Article
Journal of Radiation Protection 1985;10(2):122-0.
S-2, - (W-aminoalkylamino) ethyl 및 S-2, W-diaminoalkyl Isothiuronium Bromide 의 약독성(藥毒性)과 방사선장해방호(放射線障害防護) 효과
김유선;김석원;
Drug Toxicities of S-2-(W-aminoalkylamino) ethyl and S-2, W-diaminoalkyl Isothiuronium Bromides and their Potent Radioprotective Effects
Kim, You-Sun;Kim, Suc-Won;
ABSTRACT
S-2, W-diaminopentyl isothiuronium bromide and relevant thiophosphate derivative were prepared starting from both phthalimide and l-ornithinic acid. Drug toxicities of the prepared isothiuronium bromide and S-2-(W-aminoalkylamino) ethyl isothiuronium bromides were tested through ICR male mice, 4 and 8 weeks old and weighing $25{sim}35g$. The former compound was found to be less toxic than those of latter compounds. This difference of drug toxicities seemed to be originated from their chemical structures, which were examined through IR Spectrometry Radioprotective effects of these compounds were discussed through relevant research data and diaminopentyl derivatives are considered to be a potent radioprotectant with low drug toxicity.
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Share:      
METRICS
1,080
View
1
Download
Editorial Office
#319, Hanyang Institute of Technology Bldg., 222 Wangsimni-ro, Seongdong-gu,Seoul, Republic of Korea
Tel: +82-2-2297-9775   Fax: +82-2-2297-9776
Email: managing.editor@jrpr.org
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © by Korean Association for Radiation Protection. Developed in M2PI