Cysteamire, Isothiouronium 유도체(誘導體) 및 이들과 Phosphorothioate와의 혼합물(混合物)들의 방사선(放射線) 방호효과(防護效果)
김유선;김옥희;
Radioprotective Effects of Cysteamine, Isothiouronium Derivatives and Their Combinations with a Phosphorothioate
Kim, You-Sun;Kim, Ok-Hee;
ABSTRACT
Cysteamine(Mercaptoethyiamine, MEA), S,2-Aminoethylisothiouronium Bromide. HBr (AET), and S-(2-Aminoethyl) Dihydrogen Phosphorothioate (WR-638) were prepared and radioprotective effects of these chemicals and their combinations against $^{60}Co$${gamma}-ray$ radiation were studied ,in irradiated ICR mice. Intraperitonially administered chemicals or their combinations resulted drug deaths in cases of MEA, AET, and their combinations, whereas there were a slight or no drug death in cases of WR-638 and the combination of AET with WR-638. All tested chemicals and their combinations yielded radioprotective effects against $^{60}Co$$gamma-ray$ radiation. An additive radioprotection effect was observed in case of the combination of AET with WR-638.
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